Enter the numbers from one lipid panel to get your cholesterol/HDL ratio, non-HDL cholesterol and triglyceride/HDL ratio. It runs in your browser and sends nothing anywhere.
Cholesterol ratio = total cholesterol ÷ HDL. A total of 200 mg/dL with HDL of 50 gives 4.0. Mayo Clinic calls a ratio under 5 normal and under 3.5 ideal. The ratio is the same in mg/dL and mmol/L. The triglyceride/HDL ratio is not, which is why this calculator asks for your unit.
Only one of these four numbers has a guideline target, and it is non-HDL cholesterol. The other three are summaries. The table says where each cut-off comes from, so you can weigh it.
| Value | How it is calculated | Cut-off | Where the cut-off comes from |
|---|---|---|---|
| Cholesterol / HDL | Total cholesterol ÷ HDL | Under 5 normal, under 3.5 ideal | Mayo Clinic. Not a guideline treatment target. |
| Non-HDL cholesterol | Total cholesterol − HDL | Under 130 mg/dL (3.4 mmol/L) optimal | NCEP ATP III set it at the LDL goal plus 30 mg/dL. The 2018 AHA/ACC guideline uses non-HDL in risk assessment. |
| Triglycerides / HDL | Triglycerides ÷ HDL | 3.0 or more in mg/dL (about 1.3 in mmol/L) | A research cut-off for insulin resistance in overweight adults (McLaughlin, 2003). Not a guideline target. |
| LDL / HDL | LDL ÷ HDL | None | No guideline sets one. Guidelines treat LDL directly. |
The non-HDL bands in this calculator are the ones FixFirst's analyzer applies to an uploaded report: under 130 optimal, 130 to 159 above optimal, 160 to 189 high, 190 to 219 very high, and 220 mg/dL or more flagged for an appointment.
This is the one ratio where mg/dL and mmol/L give different answers from the same blood.
Total cholesterol, HDL and LDL all convert between mg/dL and mmol/L with the same factor, 38.67. Divide one by another and the factor cancels, so the cholesterol/HDL ratio is identical on a US or a UK report.
Triglycerides convert with a different factor, 88.57, because a triglyceride molecule is heavier than cholesterol. The factor no longer cancels. The same blood gives a TG/HDL ratio about 2.3 times higher in mg/dL than in mmol/L.
The 3.0 cut-off quoted across the internet comes from a Stanford study of 258 overweight adults whose values were in mg/dL. A UK reader with triglycerides of 1.4 mmol/L and HDL of 1.0 mmol/L gets a ratio of 1.4 and may read it as comfortably low. In mg/dL terms it is 3.2, above the cut-off. The calculator judges every result on the mg/dL basis and shows you both numbers.
mg/dL ratio = mmol/L ratio × 88.57 ÷ 38.67 ≈ mmol/L ratio × 2.29
Total cholesterol 190, HDL 40, triglycerides 160, LDL 118, all in mg/dL. Most reports would flag only the triglycerides, as borderline.
Cholesterol / HDL = 190 ÷ 40 = 4.75Non-HDL = 190 − 40 = 150 mg/dLTriglycerides / HDL = 160 ÷ 40 = 4.0LDL / HDL = 118 ÷ 40 = 2.95
Each number on its own looks close to fine. Put together, the ratios point the same way. The cholesterol/HDL ratio is inside the normal range but well above ideal. Non-HDL cholesterol is above the 130 target. The TG/HDL ratio of 4.0 is above the 3.0 research cut-off.
Low HDL with raised triglycerides is the lipid pattern that travels with insulin resistance. It is a reason to check fasting glucose, HbA1c and, if you can, fasting insulin. Our HOMA-IR calculator turns glucose and insulin into an insulin resistance score, and the high glucose with high triglycerides guide covers what to test next.
Current US guidelines do not use any of these ratios as a treatment target. The 2018 AHA/ACC cholesterol guideline sets decisions on LDL cholesterol and on overall cardiovascular risk, and uses non-HDL cholesterol and apolipoprotein B as extra information, especially when triglycerides are high. Mayo Clinic notes that many clinicians now find non-HDL cholesterol more useful than the ratio.
The ratios still earn their place as summaries. They show when a total cholesterol that looks acceptable is carried by low HDL rather than healthy HDL. The ratio can't tell you which number to work on. That is what the individual values are for. If you only have LDL left to work out, the LDL calculator takes the same three inputs.
References & Guidelines
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